This textbook uniquely blends the modern tools of organic chemistry with concepts of biology, physiology, and medicine. With a focus on human cell biology and using a problems-driven approach, the text explains the combinatorial architecture of biooligomers (genes, DNA, RNA, proteins, glycans, lipids, and terpenes) as the molecular engine for life. Accentuated by descriptions of mechanistic arrow pushing and rich illustrations, organic chemistry is used to illuminate the central dogma of molecular biology. The text contains more than 300 problems to test assimilation or the material.