This book gathers original peer-reviewed papers reporting on innovative methods and tools in design, modeling, simulation and optimization, and their applications in engineering design, manufacturing, and other relevant industrial sectors. Based on contributions to the Fifth International Conference on Design Tools and Methods in Industrial Engineering, ADM 2025, held on September 3–5, 2025, in Genova, Italy, and organized by the Italian Association of Design Methods and Tools for Industrial Engineering, this second volume of a 2-volume set focuses on design methods for medical and other applications, human factors and ergonomics, image processing and 3D technologies. It also covers advances in virtual and augmented reality, virtual prototyping and digital twins, and 3D models and geometric processing. All in all, this book provides academics and professionals with a timely overview and extensive information on trends and technologies in industrial design and manufacturing.