This book gathers original peer-reviewed papers reporting on innovative methods and tools in design, modeling, simulation and optimization, and their applications in engineering design, manufacturing, and other relevant industrial sectors. Based on contributions to the Fifth International Conference on Design Tools and Methods in Industrial Engineering, ADM 2025, held on September 3–5, 2025, in Genova, Italy, and organized by the Italian Association of Design Methods and Tools for Industrial Engineering, this first volume of a 2-volume set focuses on advances in design for additive manufacturing, product design and engineering, design for sustainability and ecoDesign. Further topics include geometric dimensioning, tolerancing, and inspection, and engineering education. All in all, this book provides academics and professionals with a timely overview and extensive information on trends and technologies in industrial design and manufacturing.