Lisa St. Clair knows a thing or two about weathering storms. A dedicated nurse with a healthy sense of humor, she single-handedly raised her truculent daughter, Marianne, after her ex walked out on them twenty-four years ago. One day he reappeared and lured their daughter into a dubious but lucrative venture in Colorado. Now mother and daughter aren't speaking.

So when Kathy Harper, Lisa's favorite patient, loses her battle with cancer, Lisa finds herself drawing closer to Carrie and Suzanne, the devoted friends who were always by Kathy's side. As these three women's lives inevitably connect, they share their concerns about men, getting older and the horrors of maintaining financial stability. Somehow their conversations always return to the enigma of Kathy. Who was she? What did her short life mean?

Lisa, Carrie, and Suzanne gradually uncover the truth of Kathy's life and unfurl plans to secure their own futures, as fate steps in to help them discover that being single doesn't have to mean being alone.