Desperate to escape a mundane future as a Virginia planter's wife, Julia Hancock seizes her chance for adventure when she wins the heart of American hero William Clark. Though her husband is the famed explorer, Julia embarks on her own thrilling and perilous journey of self-discovery.

With her gaze ever westward, Julia possesses a hunger for knowledge and a passion for helping others. She falls in love with Will's strength and generous manner, but, like her parents, he is a slave owner, and Julia harbors strong opinions against slavery. Still, her love for Will wins out, though he remains unaware of her beliefs.

Julia finds St. Louis to be a rough town with few of the luxuries to which she is accustomed, harboring scandalous politicians and miscreants of all types. As her husband and his best friend, Meriwether Lewis, work to establish an American government and plan to publish their highly anticipated memoirs, Julia struggles to assume the roles of both wife and mother. She is also drawn into the plight of an Indian family desperate to return to their own lands and becomes an advocate for Will's enslaved.

When political rivals cause trouble, Julia's clandestine aid to the Indians and enslaved of St. Louis draws unwanted attention, placing her at odds with her husband. Danger cloaks itself in far too many ways, leading her to embrace the courage to save herself and others through a challenge of forgiveness that will either restore the love she shares with Will or end it forever.