When a new doctor settles into Granite Point, he brings with him a mystery so compelling that town healer Patience is drawn to love him even as she struggles to mend him. But when Patience Sparrow's herbs and tinctures are believed to be implicated in a local tragedy, Granite Point is consumed by a long-buried fear—and its three-hundred-year-old history resurfaces as a modern-day witch hunt threatens. The plants and flowers, fruit trees, and high hedges begin to wither and die, and the entire town begins to fail; fishermen return to the harbor empty-handed, and blight descends on the old elms that line the lanes.

It seems as if Patience and her town are lost until the women of Granite Point band together to save the Sparrows. As they gather, drawing strength from each other, will they be able to turn the tide and return life to Granite Point?