When it comes to family secrets, the four Dalton sisters have had more than their share. Then quirky, spirited Uncle Edward decides to throw a seventy-fifth birthday celebration and wanders off, leaving the women to face their past—and one another.

Ellie–the eldest, tended to Uncle Edward instead of her dreams. Exasperated with his antics, aware that she's not getting any younger, is she finally ready to take off for Egypt?

Amanda–the Park Avenue snob, spent two decades raising three kids and squandering money she didn't have. Now that her husband's found a Brazilian back-waxer to take her place, will she reassess her life?

Babe–the movie-star beauty, fled New York for L.A. When she returns with her has-been actor-husband, will love and lust be reignited for her—with someone else?

Carleen–the middle-class mom, a ninth-grade algebra teacher, quilts cloth pocketbooks for fun. Did she really once have orange hair, bad boyfriends, and an attitude? Will her sisters ever forgive her for their shattered family? Or will she be forced to tell them the truth?

And will these ladies ever be able to confront their long-buried past and act like, well, sisters again?