Neil Andertol never thought playing video games would make him a real-life hero. But then his favorite game, Chameleon, turned out to be the training simulator for an actual fighter jet, and Neil and the eleven other high scorers of the game were recruited to fly a top-secret rescue mission for the United States Air Force.

Now it's been four months since Neil and his friends saved the planet, and the thirteen-year-old supernerd is back to playing video games . . . except that after piloting the real thing, he finds that even Chameleon has lost its spark. So when NASA begs for Neil's help, he says yes in a nanosecond.

This time, rescuing humankind means heading into outer space. A supersecret spacecraft has been stolen, and NASA needs the best pilots in the universe to get it back—the Nerdy Dozen. It's a race against time to stop an earth-shattering disaster. Can the twelve geeks save the day again—or will it be game over?