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Lieferstatus:	i.d.R. innert 14-24 Tagen versandfertig
Veröffentlichung:	Juni 2005
Genre:	Naturwissensch., Medizin, Technik
	B / biochemistry / Biochemistry, general / biology;genome;protein;proteins;sequencing / Biomedical and Life Sciences / Life Sciences
ISBN:	9780387251493
EAN-Code:	9780387251493
Verlag:	Springer Us
Einband:	Gebunden
Sprache:	English
Serie:	#04 - Proteases in Biology and Disease
Dimensionen:	H 241 mm / B 160 mm / D 25 mm
Gewicht:	705 gr
Seiten:	360
Zus. Info:	HC runder Rücken kaschiert
Bewertung:	Titel bewerten / Meinung schreiben

Inhalt:

The ADAM Family of Proteases provides the first comprehensive review of the roles of ADAMs and the related ADAMTS proteases in biology and disease. Although a few members of the ADAM (a disintegrin and metalloprotease) family have been known for some time, it is only in recent years through advances in genome sequencing that the large size of this family of zinc metalloproteases has become apparent. These proteins have multiple domains including a protease domain and a disintegrin domain. A branch of the family, called ADAMTS, also have thrombospondin-like motifs. The role of ADAMs and ADAMTS members in a diversity of biological processes is gradually coming to light. For example, some ADAMs have critical roles in the ectodomain shedding of membrane proteins including tumour necrosis factor-a, the cell signalling molecule Notch and the Alzheimer's amyloid precursor protein. Other ADAM and ADAMTS family members have key roles to play in sperm function and fertility, collagen processing, development, cardiac hypertrophy and arthritis.