The original work and latest achievements of the contributors, expanding on material presented at a workshop organized to coincide with the 2018 European Control Conference will assist systems and control scientists interested in developing theoretical and computational tools to solve analysis and synthesis problems involving complex dynamical systems. The contributions provide a comprehensive picture of available results along with a stimulating view of possible directions for future investigations in the field. Emphasis is placed on methods with solid computational background and on specific engineering applications so that readers from both theoretical and practical backgrounds will find this collection of use.