Übersicht			Auf mobile öffnen

Lieferstatus:	i.d.R. innert 7-14 Tagen versandfertig
Veröffentlichung:	September 2015
Genre:	Naturwissensch., Medizin, Technik
ISBN:	9783659780110
EAN-Code:	9783659780110
Verlag:	LAP Lambert Academic Publishing
Einband:	Kartoniert
Sprache:	English
Dimensionen:	H 220 mm / B 150 mm / D 9 mm
Gewicht:	221 gr
Seiten:	136
Zus. Info:	Paperback
Bewertung:	Titel bewerten / Meinung schreiben

Inhalt:

Spectrophotometry is an instrumental method of analysis that widely adopted where spectrophotometric methods of analysis are still in competition with other techniques applied for pharmaceutical analysis. Because of the lack of specific methods for the determination of amiodarone hydrochloride in the literature, it is worthy to investigate some other methods for its determination and the adaptation of these methods to be available for pharmaceutical preparations. So, the present work aims to develop new simple, accurate and sensitive spectrophotometric methods for the quantitative determination of amiodarone hydrochloride (AM.HCl) in pure form and in pharmaceutical formulations through ion-pair/associate formation reactions with some sulphonphthalein dyes. The reaction conditions were studied and optimized. The methods were successfully applied to the analysis of commercial tablets (Cordarone®). Statistical comparison of the results was performed with regard to accuracy and precision using student¿s t- and F-tests at 95% confidence level. Also, the kinetics and thermodynamic parameters of hydrolysis of AM.HCl-BCG ion- pair were studied.