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Sodium Butyrate: Compound (Chemistry), Sodium, Butyric Acid, Cellular Differentiation, Cell Growth
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(Buch) |
Dieser Artikel gilt, aufgrund seiner Grösse, beim Versand als 2 Artikel!
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| Please note that the content of this book primarily consists of articles
available from Wikipedia or other free sources online. Sodium butyrate
is a compound with formula Na(C3H7COO). It is the sodium salt of butyric
acid. It has various effects on cultured mammalian cells including
inhibition of proliferation, induction of differentiation and induction
or repression of gene expression. As such, it can be used in lab to
bring about any of these effects. Specifically, butyrate treatment of
cells results in histone hyperacetylation, and butyrate itself inhibits
HDAC activity. Butyrate has been an essential vehicle for determining
the role of histone acetylation in chromatin structure and function.
Inhibition of HDAC activity affects the expression of only 2% of
mammalian genes. |
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