Skin Hunger tells two stories in counterpoint: the story of Rowan, a young activist who crusades for animal liberation to compensate for a dearth of emotional comfort and physical connection, and that of Evie, Rowan's mother, whose struggles with mental illness and substance abuse have long kept the family apart.

Rowan Shea has spent her life looking for warmth and comfort. Separated for years from her mentally ill mother, she seeks fulfilment in caring for sick and injured animals, and connection through a string of casual hook-ups. After losing her job as a vet tech, Rowan finds a renewed sense of belonging and direction when she falls in with a group of animal rights activists and moves into their ramshackle farm on the outskirts of Vancouver. Soon, impatient with their inaction and petty disputes, Rowan forges new friendships and creates her own opportunities for protest, until she learns that the activists are targeting a university lab performing experiments on rhesus monkeys--and considering more extreme action.

In another time and another place, Rowan's mother, Evie, struggles with the conviction that her very essence will harm her delicate baby. After numerous stays in a psychiatric hospital, Evie becomes convinced that her daughter is better off without her cursed touch. Lonely yet wary of forging deep connections, Evie undertakes the challenge of building a new life on her own terms.

Skin Hunger tells the story of a mother and daughter, starved for nurturing and compassion, as they struggle to find a home in the world, one that, despite decades apart, might bring them back together.