This volume explores the relevance of Pauli's visionary ideas with respect to several topics in science and philosophy that are if great contemporary interest: the role of symmetries in theoretical science; dual-aspect approaches to the mind-brain problem; the tension between psychological and physical time; the nature of creative activity and the origin of mathematical insight; and adaptive mutations and epigenetics in biology. Today we are in a position to appreciate how relevant Pauli's work and speculations have turned out to be. This book, authored by a team of internationally renowned experts, provides material and suggests directions for future studies of a variety of deep-seated and open problems, in particular concerning the relation between mind and matter.