The advances in semiconductor detectors, scintillators, photodetectors such as SiPM, and readout electronics in the past decades have led to significant progress in terms of performance and greater choice of the detection tools in many applications. This second edition of Radiation Detection Systems presents the state-of-the-art in the design of detectors and integrated circuit design, in the context of medical imaging using ionizing radiation. The material in the book has been divided into two volumes. The first volume on Sensor Materials, Systems, Technology and Characterization Measurements puts more emphasis on sensor materials, detector and front electronics technology and designs as well as system optimization for different applications. It also includes characterization measurements of the developed detection systems. The second volume on Medical Imaging, Industrial Testing and Security Applications is devoted to more specific applications of detection systems in medical imaging, industrial testing and security applications. However, there is an unavoidable certain overlap in topics between both volumes. With its combined coverage of new materials and innovative new system approaches, as well as a succinct overview of recent developments, this two volumes set is an invaluable tool for any engineer, professional, or student working in electronics or an associated field.