This is the first book devoted exclusively to quantitative graph theory. It presents and demonstrates existing and novel methods for analyzing graphs quantitatively. Incorporating interdisciplinary knowledge from graph theory, information theory, measurement theory, and statistical techniques, this book covers a wide range of quantitative-graph theoretical concepts and methods, including those pertaining to real and random graphs. Through its broad coverage, this text fills a gap in the contemporary literature of discrete and applied mathematics, computer science, systems biology, and related disciplines.