Übersicht			Auf mobile öffnen

Lieferstatus:	Auf Bestellung (Lieferzeit unbekannt)
Veröffentlichung:	Februar 2004
Genre:	Naturwissensch., Medizin, Technik
	Arzneimittel / Biomolecules (DNA, RNA, Peptides, etc.) / Biomoleküle (DNA, RNA, Peptide) / Bioorganic Chemistry / Bioorganische Chemie / Chemie / chemistry / Drug Discovery & Development / Medizin, Gesundheit / ORGANIC CHEMISTRY / Organische Chemie / Pseudopeptid / Wirkstoffforschung u. -entwicklung
ISBN:	9783527306336
EAN-Code:	9783527306336
Verlag:	Wiley-Vch
Einband:	Gebunden
Sprache:	English
Dimensionen:	H 240 mm / B 170 mm / D 21 mm
Gewicht:	578 gr
Seiten:	256
Illustration:	Tabellen, schwarz-weiss, farbige Illustrationen, schwarz-weiss Illustrationen
Bewertung:	Titel bewerten / Meinung schreiben

Inhalt:

Peptides are among the most versatile bioactive molecules, yet the do not make good drugs, because they are quickly degraded or modified in the body. Thus, drug discovery has turned to the novel field of peptidomimetics, i. e. to design non-peptide compounds mimicking the pharmacophore and thus the activity of the original peptide. These novel compounds open up new perspectives in drug design by providing an entire range of highly specific pharmaceuticals that have a high bioavailability. In particular, the following classes of pseudo-peptides are introduced and examined with regard to their chemical properties, pharmacological activity, as well as practical aspects of synthesis: * Oligo-glycines * Beta-peptides * Gamma-peptides * Pyrrole-imidazole polyamides * DNA-like peptide nucleic acids * Alpha-helical peptide nucleic acids * DNA-cleaving pseudo-peptides The first work drawing together knowledge gained on different types of pseudo-peptides with drug properties, this book is an essential resource for drug developers and bioorganic chemists working with those compounds.