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Autor(en): 
  • Ariel Fernández
  • Physics at the Biomolecular Interface: Fundamentals for Molecular Targeted Therapy 
     

    (Buch)
    Dieser Artikel gilt, aufgrund seiner Grösse, beim Versand als 3 Artikel!


    Übersicht

    Auf mobile öffnen
     
    Lieferstatus:   i.d.R. innert 5-10 Tagen versandfertig
    Veröffentlichung:  Juni 2018  
    Genre:  Naturwissensch., Medizin, Technik 
     
    B / biochemistry / Biological and Medical Physics, Biophysics / Biological physics / Biomedical Research / Biophysics / Complex systems / Dynamical systems / Dynamics & statics / Industrial chemistry & chemical engineering / Life Sciences / Medical physics / Medical research / molecular biology / Molecular Medicine / Pharmaceutical Sciences/Technology / Pharmaceutical technology / Pharmaceutics / Physical Chemistry / Physics and Astronomy / Protein Structure / proteins / Statistical physics
    ISBN:  9783319809007 
    EAN-Code: 
    9783319809007 
    Verlag:  Springer International Publishing 
    Einband:  Kartoniert  
    Sprache:  English  
    Serie:  Soft and Biological Matter  
    Dimensionen:  H 235 mm / B 155 mm / D 28 mm 
    Gewicht:  756 gr 
    Seiten:  504 
    Zus. Info:  Paperback 
    Bewertung: Titel bewerten / Meinung schreiben
    Inhalt:
    This book focuses primarily on the role of interfacial forces in understanding biological phenomena at the molecular scale. By providing a suitable statistical mechanical apparatus to handle the biomolecular interface, the book becomes uniquely positioned to address core problems in molecular biophysics. It highlights the importance of interfacial tension in delineating a solution to the protein folding problem, in unravelling the physico-chemical basis of enzyme catalysis and protein associations, and in rationally designing molecular targeted therapies. Thus grounded in fundamental science, the book develops a powerful technological platform for drug discovery, while it is set to inspire scientists at any level in their careers determined to address the major challenges in molecular biophysics.

    The acknowledgment of how exquisitely the structure and dynamics of proteins and their aqueous environment are related attests to the overdue recognition that biomolecular phenomena cannot be effectively understood without dealing with interfacial behaviour. There is an urge to grasp how biologically relevant behaviour is shaped by the structuring of biomolecular interfaces and how interfacial tension affects the molecular events that take place in the cell. This book squarely addresses these needs from a physicist perspective.

    The book may serve as a monograph for practitioners and, alternatively, as an advanced textbook. Fruitful reading requires a background in physical chemistry and some basics in biophysics. The selected problems at the end of the chapters and the progression in conceptual difficulty make it a suitable textbook for a graduate level course or an elective course for seniors majoring in chemistry, physics, biomedical engineering or related disciplines.

      



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