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Optimization in Drug Discovery: In Vitro Methods
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(Buch) |
Dieser Artikel gilt, aufgrund seiner Grösse, beim Versand als 3 Artikel!
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| Thoroughly revised and updated,
Optimization in Drug Discovery: In Vitro Methods, Second Edition
presents a wide spectrum of in vitro assays including formulation, plasma binding, absorption and permeability, cytochrome P450 (CYP) and UDP-glucuronosyltransferases (UGT) metabolism, CYP inhibition and induction, drug transporters, drug-drug interactions via assessment of reactive metabolites, genotoxicity, and chemical and photo-mutagenicity assays. Written for the
Methods in Pharmacology and Toxicology
series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Expert authors have developed and utilized these in vitro assays to achieve "drug-like" characteristics in addition to efficacy properties and good safety profiles of drug candidates.
Comprehensive and up-to-date,
Optimization in Drug Discovery: In Vitro Methods, Second Edition
aims to guide researchers down the difficult path to successful drug discovery and development.
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