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Lieferstatus:	i.d.R. innert 14-24 Tagen versandfertig
Veröffentlichung:	August 2015
Genre:	Naturwissensch., Medizin, Technik
ISBN:	9789401771962
EAN-Code:	9789401771962
Verlag:	Springer Netherlands
Einband:	Gebunden
Sprache:	English
Serie:	#76 - Subcellular Biochemistry
Dimensionen:	H 241 mm / B 160 mm / D 27 mm
Gewicht:	869 gr
Seiten:	420
Zus. Info:	HC runder Rücken kaschiert
Bewertung:	Titel bewerten / Meinung schreiben

Inhalt:

Phosphatases such as TNAP are fundamental in regulating cellular, and consequently numerous body functions. TNAP is a ubiquitous enzyme with a wide spectrum of substrates and specificity regulation at the cellular level and the lack of TNAP activity is a lethal condition. Recent findings of a highly specific regional, laminar and subcellular localization of TNAP in the cerebral cortex indicates that in addition to its metabolic and skeletal functions, TNAP also plays a role in regulating cerebral functions, most probably cognition. In fact, TNAP disturbance could result in complex diseases such as epilepsy, developmental retardation and Alzheimer disease. Available data suggest that, regarding brain functions, TNAP is a potentially important target of clinical research. The proposed book aims to provide an overview of our current understanding of the functions of TNAP in the brain.