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Lieferstatus:	Auf Bestellung (Lieferzeit unbekannt)
Veröffentlichung:	Februar 2018
Genre:	Schulbücher
	Adaptive Design;Cancer;Dose Finding;Phase I;Phase I/II / bioinformatics / Biostatistics / C / Epidemiology & medical statistics / Life sciences# general issues / Mathematics and Statistics / Probability & statistics / Statistical Theory and Methods / Statistics / Statistics for Life Sciences, Medicine, Health Sciences / Statistics in Life Sciences, Medicine, Health Sciences mehr...
ISBN:	9784431555728
EAN-Code:	9784431555728
Verlag:	Springer EN
Einband:	Kartoniert
Sprache:	English
Serie:	JSS Research Series in Statistics SpringerBriefs in Statistics
Dimensionen:	H 235 mm / B 155 mm / D 7 mm
Gewicht:	175 gr
Seiten:	89
Illustration:	XIII, 89 p. 3 illus., schwarz-weiss Illustrationen
Zus. Info:	EUDR exemption - product or manufacturing materials placed on the market prior to 31.12.2025.
Bewertung:	Titel bewerten / Meinung schreiben

Inhalt:

This book deals with advanced methods for adaptive phase I dose-finding clinical trials for combination of two agents and molecularly targeted agents (MTAs) in oncology. It provides not only methodological aspects of the dose-finding methods, but also software implementations and practical considerations in applying these complex methods to real cancer clinical trials. Thus, the book aims to furnish researchers in biostatistics and statistical science with a good summary of recent developments of adaptive dose-finding methods as well as providing practitioners in biostatistics and clinical investigators with advanced materials for designing, conducting, monitoring, and analyzing adaptive dose-finding trials. The topics in the book are mainly related to cancer clinical trials, but many of those topics are potentially applicable or can be extended to trials for other diseases. The focus is mainly on model-based dose-finding methods for two kinds of phase I trials. One is clinical trials with combinations of two agents. Development of dose-finding methods for two-agent combination trials requires reasonable models that can adequately capture joint toxicity probabilities for two agents, taking into consideration possible interactions of the two agents on toxicity probability such as synergistic or antagonistic effects. Another is clinical trials for evaluating both efficacy and toxicity outcomes in single- and two-agent combination trials. These methods are often applied to the phase I trials including MTAs because the toxicity and efficacy for a MTA does not monotonically increase with dose, but the efficacy often increases initially with the dose and then plateaus. Successful software implementations for several dose-finding methods are introduced in the book, and their operating characteristics in practice are discussed. Recent advance of the adaptive dose-finding methods in drug developments are also provided.