Due to Jack Stapleton's ongoing recovery from his near-death confrontation with a serial killer, his wife Laurie Montgomery, the NYC Chief Medical Examiner, is carrying the load both at work and at home. When she insists an underperforming pathology resident named Ryan Sullivan assist her on a suicide autopsy, Laurie unknowingly provokes an emotional storm in the trainee.

So, when Ryan himself appears on the medical examiner's table days later, an apparent death by suicide, Laurie's guilt compels her to try to understand why. Jack's autopsy on the resident opens the disturbing possibility that the Manner of Death wasn't suicide but instead a staged homicide. But staged by whom?

Laurie ignores her own professional rules and responsibilities to investigate personally who might want Ryan dead...and for what reason. Thus begins a dangerous inquiry into a fraudulent but highly lucrative cancer diagnostics company, which might just cost Laurie her life.