Übersicht			Auf mobile öffnen

Lieferstatus:	i.d.R. innert 5-10 Tagen versandfertig
Veröffentlichung:	Februar 2017
Genre:	Psychologie / Pädagogik
	Mensch / Physiologie / Physiologie / Psychologie
ISBN:	9783736994713
EAN-Code:	9783736994713
Verlag:	Cuvillier
Einband:	Kartoniert
Sprache:	English
Dimensionen:	H 210 mm / B 148 mm / D 14 mm
Gewicht:	341 gr
Seiten:	260
Zus. Info:	Paperback
Bewertung:	Titel bewerten / Meinung schreiben

Inhalt:

The aim of the present thesis was to examine superoxide anions released by human inflammatory macrophages in individuals with essential hypertension and coronary artery disease patients with Type D personality, in order to shed more light on the mechanisms that link hypertension with an increased risk of atherosclerosis and Type D personality with poor cardiac prognosis in coronary artery disease patients, respectively. Therefore, in a first step, a simple and accurate in vitro method for the measurement of superoxide anions by human inflammatory macrophages was implemented and validated. Superoxide anion production by human inflammatory macrophages, measured by means of the reliable and valid in vitro WST-1 assay, was higher both in individuals with essential hypertension and in coronary artery disease patients with Type D personality compared to their control groups. Furthermore, mean arterial blood pressure as well as the two Type D subscales ¿negative affectivity¿ and ¿social inhibition¿, and their interaction, were associated with higher macrophage superoxide anion production. These findings suggest that superoxide anion production by inflammatory macrophages may play a mechanistic role in the mediation of both atherosclerotic risk in hypertension and poor cardiac prognosis in coronary artery disease patients with Type D personality.