This book gives a concise view on how to extend the applicability of well-known ML algorithms in Graphics Processing Unit (GPU) with data scalability in mind. It presents a series of new techniques to enhance, scale and distribute data in a Big Learning framework. It is not intended to be a comprehensive survey of the state of the art of the whole field of machine learning for Big Data. Its purpose is less ambitious and more practical: to explain and illustrate existing and novel GPU-based ML algorithms, not viewed as a universal solution for the Big Data challenges but rather as part of the answer, which may require the use of different strategies coupled together.