This book constitutes the proceedings of the 10th China Conference on Knowledge Graph and Semantic Computing, CCKS 2025, held in Fuzhou, China, during September 19–21, 2025.

The 22 full papers presented in this book were carefully reviewed and selected from 112 submissions. They were organized into the following topical sections: Knowledge Graph Construction and Integration; Large Models Enhanced by Knowledge Graphs; Applications of Knowledge Graphs and Large Models/Agents; Open Resources for Knowledge Graphs and Large Models; and Evaluations.