This book is a collection of best selected research papers presented at Fourth International Conference on Intelligent Systems and Sustainable Computing (ICISSC 2024), held in School of Engineering, Malla Reddy University, Hyderabad, India, during December 20–21, 2024. This book covers recent research in intelligent systems, intelligent business systems, soft computing, swarm intelligence, artificial intelligence and neural networks, data mining and data warehousing, cloud computing, distributed computing, big data analytics, Internet of things (IoT), machine learning, speech processing, sustainable high-performance systems, VLSI and embedded systems, image and video processing and signal processing and communication. This book is presented in two volumes.