Reflecting the large and growing pedagogical landscape in the field, this new edition contains nearly double the number of chapters of its predecessor, making it approximately twice the length while incorporating new topics. Fully updated, it remains the only book that combines and integrates an extensive set of subjects in genetics and evolution in a manner that is readily understood by students at either the graduate or undergraduate level. It provides the basic foundations of molecular evolution, including the structure and function of macromolecules such as DNA, RNA, and proteins.