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Lieferstatus:	i.d.R. innert 7-14 Tagen versandfertig
Veröffentlichung:	April 2019
Genre:	Naturwissensch., Medizin, Technik
	Biologie / Biologie, Biowissenschaften / Biowissenschaften / Chemical biology / Chemie / combinatorial synthesis / cytotoxicity / drug delivery / fluorescence / fluorescent dye / high-throughput screening / Imaging / Life Sciences / Lipinski / Mensch / Biologie / organ-specific / peptoids / Spheroids / Structure-function relationship / zebrafish mehr...
ISBN:	9783736999961
EAN-Code:	9783736999961
Verlag:	Cuvillier
Einband:	Kartoniert
Sprache:	English
Dimensionen:	H 210 mm / B 148 mm / D 11 mm
Gewicht:	244 gr
Seiten:	182
Bewertung:	Titel bewerten / Meinung schreiben

Inhalt:

Drug delivery systems can increase the pharmacokinetic and pharmacodynamic properties of various therapeutic agents. These systems can ensure a controlled release, improve the specificity of drugs to the target tissue, and therefore decrease side effects to the healthy surrounding tissue. In this work cell penetrating peptoids, which mimic the structure of peptides but exhibit increased stability, were investigated as organelle- and organ-specific carrier molecules. Several fluorescently labelled peptoid libraries, differing for example in length and side-chain composition, were synthesized and investigated with high-throughput screenings in different cell lines. The focus was on the elucidation of structure-function relationships for cellular uptake, intracellular localization and cytotoxicity. Furthermore, the organ targeting of the peptoids was analysed in in vivo studies by using zebrafish as model organism. In addition, the influence of the fluorescent dye on the localization and uptake of the peptoids was investigated.