This handbook provides an in-depth treatment of up-to-date and currently developing statistical methods for the design and analysis of case-control studies, with a primary focus on case-control studies in epidemiology. Authors will be encouraged to illustrate the statistical methods they describe by application to datasets that are either already publicly available or can be made so. A handbook website will be established that provides readers access to those datasets and software used to analyze them. Wherever feasible, authors will be asked to construct their examples using the R statistical language, though programs in SAS, Stata or other common languages will also be accepted.