Grandma Bonkers receives a call from Omar Cash-O-Kut, a descendant of the ancient Pharaoh of Egypt, King Kaputapotato. He wants the fearless and ever-victorious Granny to bring him the magical Heelosickle fruit, which cures all illnesses. Omar gives Granny a map of King Kaput's tomb, showing where the fruit grows. According to him, no one has found this place before. At first Granny denies Omar's request, but then Omar forcefully inserts a vial filled with the deadly belladonna poison behind Granny's ear. With one tap of a key on Omar's computer, he can send the poison into Granny's veins, killing her within a minute. The message is simple - get the fruit or die. Granny has no choice. And so she and her grandson, Billy, set off to raid the pharaoh's tomb.

On their quest, Granny and Billy make gruesome discoveries and encounter weird creatures with sinister motives. Will they be able to overcome the enemy and bring the Heelosickle fruit back to Omar in time before it dies?