Übersicht			Auf mobile öffnen

Lieferstatus:	Auf Bestellung (Lieferzeit unbekannt)
Veröffentlichung:	September 2014
Genre:	Naturwissensch., Medizin, Technik
	B / Biomedical and Life Sciences / Neurology / Neurology & clinical neurophysiology / Neuroscience / Neurosciences / Pharmacology / Pharmacology/Toxicology
ISBN:	9781493914258
EAN-Code:	9781493914258
Verlag:	Springer Nature EN
Einband:	Gebunden
Sprache:	English
Serie:	#27 - The Receptors
Dimensionen:	H 235 mm / B 155 mm / D
Gewicht:	5856 gr
Seiten:	295
Illustration:	IX, 295 p. 34 illus., 18 illus. in color., schwarz-weiss Illustrationen, farbige Illustrationen
Bewertung:	Titel bewerten / Meinung schreiben

Inhalt:

GABA is the principal inhibitory neurotransmitter in the CNS and acts via GABAA and GABAB receptors. Recently, a novel form of GABAA receptor-mediated inhibition, termed "tonic" inhibition, has been described. Whereas synaptic GABAA receptors underlie classical "phasic" GABAA receptor-mediated inhibition (inhibitory postsynaptic currents), tonic GABAA receptor-mediated inhibition results from the activation of extrasynaptic receptors by low concentrations of ambient GABA. Extrasynaptic GABAA receptors are composed of receptor subunits that convey biophysical properties ideally suited to the generation of persistent inhibition and are pharmacologically and functionally distinct from their synaptic counterparts. This book highlights ongoing work examining the properties of recombinant and native extrasynaptic GABAA receptors and their preferential targeting by endogenous and clinically relevant agents. In addition, it emphasizes the important role of extrasynaptic GABAA receptors in GABAergic inhibition throughout the CNS and identifies them as a major player in both physiological and pathophysiological processes.