Enterprise Interoperability X presents contributions ranging from academic research and case studies, to industrial and administrative experiences with interoperability. These contributions help organizations to analyse and improve their products and processes in the face of the high degree of uncertainty in the current commercial environment, and to predict their performance. To this end, the contributors exploit digital twin technology that integrates tools from the Internet of Things, artificial intelligence and software analytics. Enterprise interoperability necessarily arises from the processes required to make associated digital twins work together.