In spite of the advent of different approaches to devise strategies for developing stress tolerant crops towards multiple stress conditions in the field, the success in achieving this goal is still unsatisfactory. Stress tolerance is a very complex process-involving plethora of components starting from stress sensing to generation of final adaptive response. There are several factors, which act as nodes and hubs in the signaling pathways, also serving as master-control switches in regulating a myriad of stress signaling pathways by affecting diverse target genes or gene products to finally bring-about a stress tolerance response. Therefore, in-depth understanding of these master-control switches and key-components in signal transduction pathway will be highly beneficial for designing crop plants tolerant to multiple stresses in the field.