This book provides a comprehensive and systematic framework for digital twin¿driven manufacturing systems in the era of Industry 5.0. As the demand for human¿centric, resilient, and sustainable manufacturing continues to grow, Digital Twin technology is emerging as a key enabler of end¿töend digitalization across the entire product manufacturing lifecycle. Yet, despite its potential, industrial adoption still faces significant challenges, including fragmented data, limited interoperability, insufficient real¿time optimization, and concerns surrounding data security.

To address these gaps, the book clarifies core concepts and defining characteristics of digital twin¿driven systems, introduces essential enabling technologies, and presents practical methodologies for system design and implementation. It also explores advanced and emerging topics such as cross¿X manufacturing and biotwins, while discussing future opportunities shaped by the Industry 5.0 paradigm. By integrating recent research outcomes with real¿world case studies, the book serves as both a rigorous academic reference and a practical guide for researchers, engineers, and industry professionals.