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Lieferstatus:	i.d.R. innert 14-24 Tagen versandfertig
Veröffentlichung:	September 2019
Genre:	Naturwissensch., Medizin, Technik
	Atomic and Molecular Structure and Properties / Atomic structure / Atomic/Molecular Structure and Spectra / B / Biomathematics / Chemistry, Physical and theoretical / Mathematical and Computational Biology / Maths for scientists / Molecular structure / Nanophysics / Nanoscale science / Nanoscale Science and Technology / Nanoscience / Nanostructures / Nuclear physics / Physics and Astronomy / Quantum & theoretical chemistry / Theoretical and Computational Chemistry / Theoretical Chemistry
ISBN:	9783030254124
EAN-Code:	9783030254124
Verlag:	Springer International Publishing
Einband:	Gebunden
Sprache:	English
Serie:	Springer Theses
Dimensionen:	H 241 mm / B 160 mm / D 15 mm
Gewicht:	412 gr
Seiten:	160
Zus. Info:	HC runder Rücken kaschiert
Bewertung:	Titel bewerten / Meinung schreiben

Inhalt:

The interactions of DNA with force are central to manifold fields of inquiry, including the de novo design of DNA nanostructures, the use of DNA to probe the principles of biological self-assembly, and the operation of cellular nanomachines. This work presents a survey of three distinct ways coarse-grained simulations can help characterize these interactions. A non-equilibrium energy landscape reconstruction technique is validated for use with the oxDNA model and a practical framework to guide future applications is established. A novel method for calculating entropic forces in DNA molecules is outlined and contrasted with existing, flawed approaches. Finally, a joint experimental-simulation study of large DNA origami nanostructures under force sheds light on design principles and, through vivid illustrations, their unfolding process. This text provides an accessible and exciting launching point for any student interested in the computational study of DNA mechanics and force interactions.