The background emphasizes the need for site-specific drug delivery systems that overcome limitations of conventional therapies, including poor bioavailability and systemic toxicity. Core-shell nanoparticles, with their layered design, improve drug encapsulation, stability, and biocompatibility while enabling controlled release. Their development reflects decades of progress in nanotechnology, pharmaceutics, and biomedical engineering, converging toward personalized and precision medicine.

Chapters span principles of targeted delivery, ligand-mediated strategies, and applications in personalized medicine, followed by organ-specific therapies for cancer, neurological disorders, and metabolic or endocrine diseases. Additional sections address preclinical models, clinical trials, nanotoxicology, regulatory perspectives, and commercialization challenges, enriched by contributions from international experts.

The audience includes researchers, pharmaceutical scientists, clinicians, and graduate students in nanomedicine, drug delivery, and biomaterials. Secondary readers such as healthcare professionals, industry innovators, and policymakers will also benefit. By combining foundational knowledge with translational case studies, this volume serves as both a scholarly reference and a practical guide for advancing smart therapeutics.