This book presents the latest research in computational biology and bioinformatics, with a thematic focus on gene regulation. It is designed to be self-contained and comprehensive, targeting senior undergraduates and junior graduate students in the related disciplines such as bioinformatics, computational biology, biostatistics, genome science, computer science, applied data mining, applied machine learning, life science, biomedical science, and genetics. In addition, this book serves as a useful reference for both bioinformaticians and computational biologists.