The book groups chapters based on the major foci of the core content: health care delivery and policy; clinical decision-making; information science and systems; data management and analytics; leadership and managing teams; and professionalism. The chapters do not need to be read or taught in order, although the suggested order is consistent with how the editors have structured their curricula over the years.

Clinical Informatics Study Guide: Text and Review serves as a reference for those seeking to study for a certifying examination independently or periodically reference while in practice. This includes physicians studying for board examination in clinical informatics as well as the American Medical Informatics Association (AMIA) health informatics certification. This new edition further refines its place as a roadmap for faculty who wish to go deeper in courses designed for physician fellows or graduate students in a variety of clinically oriented informatics disciplines, such as nursing, dentistry, pharmacy, radiology, health administration and public health.