The book is divided into three sections:  classification, disease, and evidence. In general, attention is focused on statistics in medicine and epidemiology, issues in psychiatry, and connecting medicine with evolutionary biology and genetics. Many authors position the theories that they address within their historical contexts.

The nature of health and disease will be addressed in several essays that also touch upon very general questions about the definition of medicine and its status.  Several chapters scrutinize classification because of its centrality within philosophical problems raised by medicine and its core position in the philosophical questioning of psychiatry. Specificities of medical explanation have recently come under a new light, particularly because of the rise of statistical methods, and several chapters investigate these methods in specific contexts such as epidemiology or meta-analysis of random testing. Taken together this collection addresses the question of how we gather, use and assess evidence for various medical theories.

The rich assortment of disciplines featured also includes epidemiology, parasitology, and public health, while technical aspects such as the application of game theory to medical research and the misuse of the DSM in forensic psychiatry are also given an airing. The book addresses more than the construction of medical knowledge, however, adding cogent appraisal of the processes of decision making in medicine and the protocols used to justify therapeutic choices.