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Antibody FC: Linking Adaptive and Innate Immunity
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Dieser Artikel gilt, aufgrund seiner Grösse, beim Versand als 3 Artikel!
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This is the first comprehensive text to synthesize the literature, describing these functions and presenting the variety of human genetic, mouse model in vitro and providing clinical evidence of the importance and dramatic variability of antibodies to influence the immune response. Antibodies represent the correlate of protection for numerous vaccines and are the most rapidly growing class of drugs, representing a tremendous economic and therapeutic sector ranging from cancer and infectious disease to autoimmunity. Researchers have long understood the variable domain of antibodies, which are responsible for antigen recognition, and can provide protection by blocking the function of their target antigen. However, recent developments in our understanding of the protection mediated by antibodies have highlighted the critical nature of the antibody constant, or Fc domain, in the biological activity of antibodies. The Fc domain allows antibodies to link the adaptive and innate immune systems, providing specificity to a wide range of innate effector cells as well as providing a feedback loop to regulate the character of the immune response via interactions with B cells and antigen-presenting cells. Despite its nomenclature, several factors influence the ability of the constant domain to recruit effector mechanisms. There is a vast literature regarding antibody effector function indicating that it is a high impact and dynamic area.
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