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Artikel-Nr. 16882349

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  • M. Kurowski
  • Adverse Reactions to Non-Steroidal Anti-Inflammatory Drugs: Clinical Pharmacoepidemiology 

    Dieser Artikel gilt, aufgrund seiner Grösse, beim Versand als 2 Artikel!


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    Lieferstatus:   i.d.R. innert 14-24 Tagen versandfertig
    Genre:  Religion 
    ISBN:  9783034857246 
    Verlag:  Birkhäuser Basel 
    Einband:  Kartoniert  
    Sprache:  English  
    Dimensionen:  H 244 mm / B 170 mm / D 6 mm 
    Gewicht:  216 gr 
    Seiten:  116 
    Zus. Info:  Paperback 
    Bewertung: Titel bewerten / Meinung schreiben
    Non-steroidal anti-inflammatory drugs (NSAIDs) are among the mostfrequently­ prescribed drugs in the Western world. During the past decade a large number of new compounds were marketed, some of which had to be withdrawn after a short while because of adverse drug reactions. These experiences led to an under­ standing that a complete picture of the safety of these drugs can only be obtained after their introduction into the marketplace. Differentmethods ofpost-marketing surveillance (PMS) serve as important tools for monitoring the frequency of adverse reactions and for generating and corroborating hypotheses. Experience with PMS has thusfar been quite limited in Germany. In 1987 a non-profit organization, "Verein zur Langzeituntersuchung von Arzneimittel­ wirkungen auf dem Gebiet der Rheumatologie e. V. " (VLAR) was founded by interested physicians and pharmacologists to raise funds and perform investiga­ tions on the safety of NSAIDs. The first project by the VLAR, SPALA ("Safety Profile of Antirheumatics in Long-Term Administration"), was sponsored by F. Hoffmann-La Roche AG (Basel, Switzerland). In July 1990, when the project was successfully terminated, almost 30,000 patients had been completely docu­ mented and their medical records entered into a computer for subsequent review by a select panel of experts with experience in monitoring adverse reactions to NSAIDs. The comments, criticisms, and ideas of these experts were brought togetherat a symposium organized by the VLAR at the Klinikum Steglitz (Berlin, Germany) on 12 October 1990.


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