Covering even more adaptive designs, this second edition offers a detailed framework to understand the use of various adaptive design methods in clinical trials. It includes 12 new chapters, more analytical methods, 20 new SAS macros and R functions, and enhanced end-of-chapter problems that give readers hands-on practice addressing issues encountered in designing real-life adaptive trials. The book compares various methods using SAS and R simulations and explains how to analyze data in adaptive trials.