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A Computational Biology Strategy For Deciphering The Biomolecular And Genomic Mechanisms Of Aggressive Cancer
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| Abnormal Clonal Proliferation of cells of the hematopoietic lineage in the bone marrow leads to blood cancer, known as Leukemia. These abnormal white blood cells (WBCs) are not fully developed and are clinically referred to as blasts. In addition to a well-known genetic predisposition, there are other environmental risk factors such as exposure to Ionizing radiation, benzene, formaldehyde etc. Based on the lineage of origin, Leukemia is broadly categorized into four types; acute myelogenous (AML), chronic myelogenous (CML), acute lymphoblastic (ALL), and chronic lymphoblastic (ALL) and 95% of all leukemias are acute. ALL is more common in children than in adults [1][2]. According to Globocan statistics, Asia is the most significant contributor to Leukemia cases (48.6%), with India having the 3rd largest Incidence rate (~10.2%) worldwide [3] . Myeloid leukemias are common in India and lymphoid in the Caucasian population, along with an uneven distribution of the percentage of cases between adults and children[4,5]. |
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