Übersicht			Auf mobile öffnen

Lieferstatus:	Auf Bestellung (Lieferzeit unbekannt)
Veröffentlichung:	Juni 2013
Genre:	Naturwissensch., Medizin, Technik
	Catalysis / Chemie / CHEMISCHE SYNTHESE / chemistry / Coordination Chemistry / Industrial Chemistry / Katalyse / Koordinationschemie / Methods - Synthesis & Techniques / Natural Products / Naturstoffchemie / Organische Chemie / Organische Chemie / Methoden, Synthesen, Verfahren / Pharmaceutical & Medicinal Chemistry / Pharmazeutische u. Medizinische Chemie / Technische u. Industrielle Chemie
ISBN:	9783527318612
EAN-Code:	9783527318612
Verlag:	Wiley-Vch
Einband:	Gebunden
Sprache:	English
Dimensionen:	H 240 mm / B 170 mm / D 30 mm
Gewicht:	1180 gr
Seiten:	488
Bewertung:	Titel bewerten / Meinung schreiben

Inhalt:

Nucleophilic Aromatic Substitutions (SNAr) represent a class of reactions of crucial importance in organic synthesis. This book provides a comprehensive overview of this versatile field, focusing on the mechanistic and synthetic features that govern these reactions. The first chapter presents a detailed mechanistic analysis of the factors determining the feasibility of SNAr substitutions, providing decisive information to predict regioselectivity of many reactions and to defi ne the conditions for concerted SNAr processes. Reflecting the key role played by these species as intermediates in most SNAr reactions, Chapter 2 then discusses the chemistry of anionic sigma-complexes. Chapter 3 describes the concept of superelectrophilicity in SNAr substitutions, as it has recently emerged from the reactivity of strongly electron-defi cient aromatic and heteroaromatic structures. The numerous synthetic applications are considered in depth in the Chapters 4 and 5 that follow on intermolecular and intramolecular nucleophilic aromatic substitutions. Then, Chapter 6 focuses on substitutions proceeding formally through displacement of a hydride ion, a hot topic in the field. The final chapter brings together concise yet comprehensive discussions surrounding SNAr photosubstitutions, radical substitutions, and ANRORC substitutions. Each Chapter starts with a short general introduction to the topics discussed. Authored by a highly respected chemist who has contributed greatly to the field over the past two decades, this is a valuable information source for all organic chemists working in academia or the pharmaceutical and agrochemical industries.