Übersicht			Auf mobile öffnen

Lieferstatus:	i.d.R. innert 14-24 Tagen versandfertig
Veröffentlichung:	Januar 2016
Genre:	Naturwissensch., Medizin, Technik
	Biopharmaceuticals & Pharmaceutical Biotechnology / Biopharmazeutika u. Pharmazeutische Biotechnologie / Biowissenschaften / Cell & Molecular Biology / Chemie / chemistry / Clinical Pharmacology & Therapeutics / Klinische Pharmakologie u. Therapie / Life Sciences / Medical Science / Medizin / Pharmakokinetik / Pharmakologie / Zell- u. Molekularbiologie
ISBN:	9781118898642
EAN-Code:	9781118898642
Verlag:	John Wiley & Sons Inc
Einband:	Gebunden
Sprache:	English
Dimensionen:	H 225 mm / B 287 mm / D 30 mm
Gewicht:	1328 gr
Seiten:	480
Bewertung:	Titel bewerten / Meinung schreiben

Inhalt:

With an emphasis on the fundamental and practical aspects of ADME for therapeutic proteins, this book helps readers strategize, plan and implement translational research for biologic drugs. * Details cutting-edge ADME (absorption, distribution, metabolism and excretion) and PKPD (pharmacokinetic / pharmacodynamics) modeling for biologic drugs * Combines theoretical with practical aspects of ADME in biologic drug discovery and development and compares innovator biologics with biosimilar biologics and small molecules with biologics, giving a lessons-learned perspective * Includes case studies about leveraging ADME to improve biologics drug development for monoclonal antibodies, fusion proteins, pegylated proteins, ADCs, bispecifics, and vaccines * Presents regulatory expectations and industry perspectives for developing biologic drugs in USA, EU, and Japan * Provides mechanistic insight into biodistribution and target-driven pharmacokinetics in important sites of action such as tumors and the brain