In Eisner-nominated Fumi Yoshinaga's alternative history of
Edo-era Japan, the men of Japan are dying out, and the women
have taken up the reigns of power-including the shogun's
seat!

In Edo period Japan, a strange new disease called the Redface Pox
has begun to prey on the country's men. Within eighty years of the
first outbreak, the male population has fallen by seventy-five percent.
Women have taken on all the roles traditionally granted to men, even
that of the shogun. The men, precious providers of life, are carefully
protected. And the most beautiful of the men are sent to serve in the
shogun's Inner Chamber...

Ienari is determined to see his country safe from the scourge of the
Redface Pox, but his mother's cruel grasp on the reigns of the power
of the shogunate means he must act in the shadows to achieve his
lofty goals. And now that he has finally convinced the banished Inner
Chamber scholars that he is sincere in his aims, perhaps a cure is
finally within sight!