Welcome back to Wayside School! After closing for 242 days to get rid of the cows (don't ask), everyone's favorite thirty-story school is finally back in session.

But all is not well at the school with no nineteenth floor. Mrs. Jewls, the best teacher at Wayside, is having a baby, and that can mean only one thing -- substitute teachers.

First comes Mr. Gorf. Was he married to the terrible Mrs. Gorf? And why does he have three nostrils? The kids won't tell you. They're not talking.

Then there's Mrs. Drazil. She never forgets a missed homework assignment, not even one that Louis the yard teacher owed her fifteen years ago.

By the time the class gets the fearsome Miss Nogard, the kids can't wait for everything to return to normal.

Wayside School may seem like a pretty strange place already, but now it has to get a little stranger.