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Herausgeber: 
  • Lorenza González-Mariscal
  • Tight Junctions 
     

    (Buch)
    Dieser Artikel gilt, aufgrund seiner Grösse, beim Versand als 3 Artikel!


    Übersicht

    Auf mobile öffnen
     
    Lieferstatus:   Auf Bestellung (Lieferzeit unbekannt)
    Veröffentlichung:  2006  
    Genre:  Naturwissensch., Medizin, Technik 
     
    Biomedical and Life Sciences / Biomedical Research / C / Cancer Research / Cell Biology / Neurobiology / Neuroscience / Neurosciences / Oncology / Pharmacology / Pharmacology/Toxicology / Zoology
    ISBN:  9780387332017 
    EAN-Code: 
    9780387332017 
    Verlag:  Springer Nature EN 
    Einband:  Gebunden  
    Sprache:  English  
    Serie:  Molecular Biology Intelligence Unit  
    Dimensionen:  H 235 mm / B 155 mm / D  
    Gewicht:  638 gr 
    Seiten:  224 
    Illustration:  XI, 224 p., Tabellen, schwarz-weiss 
    Bewertung: Titel bewerten / Meinung schreiben
    Inhalt:
    ight junctions (TJs) are cell-ceil adhesion belts that encircle epithelial and endothelial cells at the limit between the apical and the lateral Tmembrane. These junctions are crucial for the establishment of separate compartments in multicellular organisms and for the exchange of substances between the internal milieu and the external environment. The perception of TJs has changed over the years. From being regarded as static paracellular seals, they have come to be perceived as dynamic structures that adjust their morphol­ ogy and function in response to physiological, pharmacological and pathologi­ cal challenges. The roles that TJs play in epithelial and endothelial cells has also widened, and nowadays this structure is regarded not only as a fence that limits within the membrane, the movement of proteins and lipids between the apical and basolateral membranes, or as a gate that regulates in a size and charge selec­ tive manner the transit of ion and molecules through the paracellular pathway, but also as a structure integrated by molecules that participate in the control of cell proliferation. These observations highlight the importance of understand­ ing TJ physiology in order to develop effective strategies for the treatment of pathological conditions such as cancer and autoimmune diseases. This broader perception of TJs is reflected in all the chapters of the book and has been attained thanks to the identification in recent years of a wide array of proteins that constitute TJs in epithelial and endothelial cells as well as in central nervous system myelin.

      
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