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Lieferstatus:	i.d.R. innert 14-24 Tagen versandfertig
Veröffentlichung:	März 2020
Genre:	Naturwissensch., Medizin, Technik
	Biochemie / MEDICAL / Genetics / Organische Chemie / Science / SCIENCE / Chemistry / Organic / SCIENCE / Life Sciences / Biochemistry
ISBN:	9789811525087
EAN-Code:	9789811525087
Verlag:	Springer Nature Singapore
Einband:	Gebunden
Sprache:	English
Dimensionen:	H 241 mm / B 160 mm / D 16 mm
Gewicht:	448 gr
Seiten:	184
Zus. Info:	HC runder Rücken kaschiert
Bewertung:	Titel bewerten / Meinung schreiben

Inhalt:

This book presents pioneering findings on the characterization of cellular regulation and function for three recently identified protein posttranslational modifications (PTMs): lysine malonylation (Kmal), glutarylation (Kglu) and crotonylation (Kcr). It addresses three main topics: (i) Detecting Kmal substrates using a chemical reporter, which provides important information regarding the complex cellular networks modulated by Kmal; (ii) Identifying Kglu as a new histone PTM and assessing the direct impact of histone Kglu on chromatin structure and dynamics; and (iii) Revealing Sirt3¿s value as a regulating enzyme for histone Kcr dynamics and gene transcription, which opens new avenues for examining the physiological significance of histone Kcr. Taken together, these studies provide information critical to understanding how these protein PTMs are associated with various human diseases, and to identifying therapeutic targets for the dysregulation of these novel protein markers in varioushuman diseases.