This book gathers high-quality papers presented at the Third International Conference on Smart Computing and Informatics (SCI 2018-19), which was organized by the School of Computer Engineering and School of Computer Application, Kalinga Institute of Industrial Technology, Bhubaneswar, India, on 21-22 December, 2018. It includes advanced and multi-disciplinary research on the design of smart computing and informatics. Thematically, the book broadly focuses on several innovation paradigms in system knowledge, intelligence and sustainability that can help to provide realistic solutions to various problems confronting society, the environment, and industry. The respective papers offer valuable insights into the how emerging computational and knowledge transfer approaches can be used to deliver optimal solutions in science, technology and healthcare.